姜 凯
工作单位：william威廉官网
单位地址：昆明市呈贡区大学城东外环南路
邮 编：650500
电子邮箱：jiangk*ynu.edu.cn（将*替换成@）
一、 个人情况介绍
博士、研究员、东陆骨干教授、博士生导师。2007年毕业于四川农业老员工物技术专业，获理学学士学位。2010年于四川农业老员工物化学与分子生物学专业获理学硕士学位。2014年获东京大学应用生命化学专业农学博士学位。先后任职于东京大学农学与生命科学研究科特任研究员、特任助教，南方科技老员工命科学公司研究助理教授、副教授。2023年12月入职william威廉官网至今。先后入选深圳市高层次人才和云南省兴滇人才计划。截至目前，以第一作者或通讯作者（含共同）在PNAS、Nature Communications、Plant Cell、Plant Physiology、Journal of Integrative Plant Biology、Current Opinion in Plant Biology等期刊发表学术论文18篇，以共同作者身份在Cell、Nature Chemical Biology、Science Advances、Molecular Plants、New Phytologist、Plant Journal等期刊发表论文22篇，获批专利6项。先后主持国家自然科学基金青年和面上项目，云南省基础研究计划面上和青年项目（A类）。作为核心成员参与广东省引进创新创业团队项目、国家自然科学基金重点项目、国际交流项目等多项省部级、国家级科研课题。担任Frontiers in Plant Science副主编、Journal of Pesticide Science海外编委、Plant Hormones及Advanced AgroChem青年编委。长期承担Plant Physiology、Plant & Cell Physiology、Plos Genetics等学术期刊的审稿工作。
二、招生专业
（1）生物化学与分子生物学 博士、硕士（含西联专项）
（2）生物与医药 博士、硕士
（欢迎各学科背景、对药物筛选及生物交叉领域抱有兴趣的同学加入课题组！）
三、研究方向
主要从事植物激素信号转导与植物生长发育机制研究。综合运用经典遗传学、化学遗传学、有机化学、结构生物学、计算化学等多学科研究方法，结合传统湿实验与计算机辅助干实验手段，开展活性小分子化合物的筛选与理性设计开发工作。
化合物筛选流程
研究内容：
（1）活性小分子化合物高通量筛选及其作用机制研究；
（2）利用化学遗传学手段解析植物生长发育与表观遗传调控机制；
（3）新型植物生长调节剂研发及其在植物发育调控、农产品采后保鲜中的应用；
（4）人类疾病相关先导化合物的发现。
四、代表论文
一作/通讯（含共同）：
1. Liu Z*, Li Z*, Wang Y*, Long Y, Zhao H, Qin Y, Zhu X, Guo H#, Jiang K#, and Zhai J#. Cell-type Specific Early Perception of Nine Phytohormones Revealed by Single-nucleus Transcriptomics in Arabidopsis. Nature Communications, 2026, in press.
2. Yu Y and Jiang K#. Metabolic mediators at the nexus: how SAM, acetyl-CoA, and NAD+ bridge phytohormone signaling and epigenetic regulation. Current Opinion in Plant Biology. 2026, 89:102832.
3. Aizezi Y, Zhao H, Zhang Z, Bi Y, Yang Q, Guo G, Zhang H, Guo H, Jiang K# and Wang Z#. Structure-based virtual screening identifies small molecule inhibitors of O-fucosyltransferase SPINDLY. Plant Cell. 2024, 36(3): 479-509.
4. Ke D*, Xie Y*, Li H, Hu L, He Y, Guo C, Zhai Y, Guo J, Li K, Chu Z, Zhang J, Zhang X, Al-Balili S, Jiang K#, Miao Y#, Jia K#. Anchorene, a carotenoid-derived growth regulator, modulates auxin homeostasis by suppressing GH3-mediated auxin conjugation. Journal of Integrative Plant Biology. 2024, 66(11): 2490-2504.
5. Jiang K#, Guo H, and Zhai J#. Interplay of phytohormones and epigenetic regulation: A recipe for plant development and plasticity. Journal of Integrative Plant Biology. 2023, 65(2): 381-398.
6. Aizezi Y, Shu H, Zhang L, Zhao H, Peng Y, Lan H, Xie Y, Li J, Wang Y, Guo H#, and Jiang K#. Cytokinin regulates apical hook development via the coordinated actions of EIN3/EIL1 and PIF transcription factors in Arabidopsis. Journal of Experimental Botany. 2022, 73(1): 213-227. (封面文章)
7. Xie Y*, Zhu Y*, Wang N*, Luo M, Ota T, Guo R, Yu Z, Aizezi Y, Zhang L, Zhang Y, Bao H, Wang Y, Zhu Z, Huang A, Zhao Y, Asami T, Huang H, Guo H#, and Jiang K#. Chemical genetic screening identifies nalacin as an inhibitor of GH3 amido synthetase for auxin conjugation. Proceedings of the National Academy of Sciences U.S.A. 2022, 119 (49) e2209256119.
8. Zhu Y, Li H, Su Q, Wen J, Wang Y, Song W, Xie Y, He W, Yang Z, Jiang K#, Guo H#. A phenotype-directed chemical screen identifies ponalrestat as an inhibitor of the plant flavin monooxygenase YUCCA in auxin biosynthesis. Journal of Biological Chemistry. 2019, 294(52): 19923-19933.
9. Jiang K*, Otani M*, Shimotakahara H, Yoon JM, Park SH, Miyaji T, Nakano T, Nakamura H, Nakajima M, Asami T#. Substituted phthalimide AC94377 is a selective agonist of the gibberellin receptor GID1. Plant Physiology. 2017, 173(1): 825-835.
10. Takeuchi J*, Jiang K*, Hirabayashi K*, Imamura Y, Wu Y, Xu Y, Miyakawa T, Nakamura H, Tanokura M, Asami T#. Rationally Designed Strigolactone Analogs as Antagonists of the D14 Receptor. Plant and Cell Physiology. 2018, 59(8): 1545-1554.
11. Jiang K and Asami T#. Chemical regulators of plant hormones and their applications in basic research and agriculture. Bioscience Biotechnology and Biochemistry. 2018, 82(8): 1265-1300. (封面文章)
12. Jiang K, Kurimoto T, Seo EK, Miyazaki S, Nakajima M, Nakamura H, Asami T#. Development of Inhibitors of Salicylic Acid Signaling. Journal of Agricultural and Food Chemistry. 2015, 63(32): 7124-33.
共同作者：
1. Hao D, Xiao Z, Yan W, Pan C, Yang Y, Song W, Chen Z, Xing Y, Jin L, Peng Y, Qiu Y, Jiang K, Wen X, Huang K, Xiao S, Chen H, Guo H#. Sensing endoplasmic reticulum redox state by ethylene receptors. Cell. 2026, in press.
2. Wang C, Chi C, Liu Y, Zhao J, Wang Q, Wang N, Zhang Z, Jiang K, Xue Y, Li Y, Wang P, Zhai J, Guo H, Du J#. Molecular basis of DRB4-assisted long RNA processing and 21-nt siRNA biogenesis by DCL4 in plants. Nature plants. 2026, in press.
3. Song X, Zhang S, Yue Z, Liu Y, Chen S, Niu Y, Shi Y, Yang H, Xu J, Miao Y, Xu M, Zhou Y, Xu L, Liu N, Lv M, Li J, Wang T, Sun B, Qiu C, Xu R, Zhang R, Wang J, Jiang K, Fang L, Zhang H, Hou S, Li G, Chen H, Deng XW, and Li B#. Super-resolution multimodal spatial transcriptomics reveals an ovoid stem-cell niche structuring de novo shoot regeneration. Molecular Plants. 2026 in press.
4. Zhang H, Zhang B, Zhao Y, Su Y, Peng Y, Yang X, Zhao H, Liu H, Feng J, Pei H, Zhang W, Huang N, Jiang K, Ito M, Liu G, Jork N, Anderson K, Nagata E, Jessen H, Hawkings P, Du C, Rao F. Oncometabolite 5-IP7 inhibits inositol 5-phosphatase to license E-cadherin endocytosis. Nature Chemical Biology. 2026, 22, 293–306.
5. Yang Y, Kong Q, Liu C, Wang F, Li M, Li S, Shi Y, Krall L, Wang X, He S, Jiang K, Wu X, Yang M, Yang C. Homocysteine disrupts lysosomal function by V-ATPase inhibition. Journal of Cell Biology. 2026, 225 (1): e202503081.
6. Yan Y, Tian B, Li X, Wang Y, Shi Y, Jiang K, Zhai R, Davies K, Ma F, Atkinson R, Li P. The polyphenol trade-off: leaf protection vs fruit attraction in apples driven by the phlorizin glycosyltransferase PGGT1. New Phytologist. 2026, 250: 591–601.
7. Wang J, Takahashi I, Kikuzato K, Sakai T, Zhu Z, Jiang K, Nakamura H, Nakano T, Tanokura M, Miyakawa T, Asami T. Identification and structure-guided development of triazole urea-based selective antagonists of Arabidopsis karrikin signaling. Nature Communications. 2025, 16(104).
8. Liang W, Huang S, Chen X, Jiang K, Gong X, Guo H, Li L. The small-molecule pifithrin-α deactivates ETR1 to repress shade avoidance in Arabidopsis. Science Advances. 2025, 11(33), 1-11.
9. Chen W, Yan W, Jiang K, Huang H. Molecular insights into DNA recognition by HD-Zip transcription factors. Plant Physiology. 2025, 198, kiaf292.
10. Liu C, Hao D, Sun R, Zhang Y, Peng Y, Yuan Y, Jiang K, Li W, Wen X#, and Guo H#. Arabidopsis NPF2.13 functions as a critical transporter of bacterial natural compound tunicamycin in plant-microbe interaction. New Phytologist. 2023, 238:765–780.
11. Liu L*, Song W*, Huang S, Jiang K, Moriwaki Y, Wang Y, Men Y, Zhang D, Wen X, Han Z, Chai J#, Guo H#. Extracellular pH sensing by plant cell-surface peptide-receptor complexes. Cell. 2022, 185(18), 3341-3355.
12. Zheng L, Meng J, Jiang K, Lan H, Wang Z, Lin M, Li W, Guo H, Wei Y#, and Mu Y#. Improving protein-ligand docking and screening accuracies by incorporating a scoring function correction term. Briefings in Bioinformatics. 2022, 23(3), 1–15.
13. Zhou Y, Zhong Y, Li L, Jiang K, Gao J, Zhong K#, Pan M#, and Yan B. A multifunctional chitosan-derived conformal coating for the preservation of passion fruit. LWT-Food Science and Technology. 2022, 163, 113584.
14. Watanabe D*, Takahashi I*, Jaroensanti-Tanaka N, Miyazaki S, Jiang K, Nakayasu M, Wada M, Asami T, Mizutani M, Okada K, Nakajima M. The apple gene responsible for columnar tree shape reduces the abundance of biologically active gibberellin. The Plant Journal. 2021, 105:1026-1034.
15. Nakamura H*, Hirabayashi K*, Miyakawa T, Kikuzato K, Hu W, Xu Y, Jiang K, Takahashi I, Niiyama R, Dohmae N, Tanokura M, Asami T. #. Triazole ureas covalently bind to strigolactone receptor and antagonize strigolactone responses. Molecular Plant. 2019, 12(1):44-58.
16. Jamil M, Kountche BA, Haider I, Guo X, Ntui VO, Jia KP, Ali S, Hameed US, Nakamura H, Lyu Y, Jiang K, Hirabayashi K, Tanokura M, Arold ST, Asami T, Al-Babili S#. Methyl phenlactonoates are efficient strigolactone analogs with simple structure. Journal of Experimental Botany. 2018, 69(9):2319-2331.
(*第一作者、 #通讯作者)
五、专利
1. 小分子化合物在促进植物生长发育中的应用，专利号：ZL202110040713.0.
2. 杂环苯甲酰胺类化合物及其在促进植物生长发育中的应用，专利号：ZL 2022 1 0064182.3.
3. PIFs的暗处稳定剂在促进双子叶植物顶端弯钩发育中的应用，专利号：ZL202110581494.4.
4. NRT1.7基因表达的抑制剂在制备衣霉素吸收抑制剂中的应用，专利号：ZL202110678271.2.
5. 一种土甘草提取物在制备果蔬保鲜剂中的应用，专利号：ZL202011596465.X.
6. 防治水稻稻瘟病和纹枯病的芽胞杆菌菌株, 专利号：ZL201010028132.7.
